This page was produced as an assignment for Genetics 677, an undergraduate course at UW-Madison.


Figure 1. 3D structure of the ANF receptor domain of the GRM7 protein. The computer-generated diagram above is based on the crystal stucture of amino acid positions 40 to 511 of human GRM7, which corresponds to the ligand binding region (ANF receptor domain) of the protein. (Muto, et al., 2007; Kopp, et al., 2006; Kopp, et al., 2004).

Biological Roles of GRM7

Gene Ontology
MicroArray data on GRM7
Mutant Phenotypes
Chemical Genetics


Literature on Alcoholism

Popular Press Review
Scientific Article Review
Popular Press vs. Scientific Article Critque




Muto, T.,  Tsuchiya, D.,  Morikawa, K.,  Jingami, H. (2007) Structures of the extracellular regions of the group II/III metabotropic glutamate receptors Proceedings of the National Academy of Science USA 104(10):3759. doi:10.1073/pnas.0609211104.

Kopp, J., Schwede, T. (2004). The SWISS-MODEL Repository of annotated three-dimensional protein structure homology models. Nucleic Acids Research, 32(Database issue):D230. doi:10.1093/nar/gkh008.

Kopp, J., and Schwede, T. (2006). The SWISS-MODEL Repository: new features and functionalities. Nucleic Acids Research, 34(Database issue):D315. doi:10.1093/nar/gkj056.

Jennifer Wagner
Updated May 14, 2009